Avatar

Nan-Hung Hsieh

Ph.D

Biography

Nan-Hung Hsieh is a Toxicologist. His research focuses on uncertainty/variability and probabilistic modeling in quantitative systems toxicology/pharmacology. He is also a developer, contributor, and reviewer for some open-source software.

Interests

  • Pharmacokinetics
  • Bayesian Statistics
  • Open Source Software

Education

  • PhD in Bioenvironmental Systems Engineering

    National Taiwan University

  • MSc in Bioenvironmental Systems Engineering

    National Taiwan University

  • BSc in Safety, Health and Environmental Engineering

    National United University

Talks

Pharmacokinetic modeling of chemicals

Modern Open Source Tools for State-of-the-Art Risk Assessment Workshop
Dec 9, 2019 9:30 AM — 4:30 AM Arlington County, Virginia
slides - 01 slides - 02 source code

Uncertainty, Variability, and Sensitivity Analyses in Toxicological Modeling

Oct 2, 2019 10:00 AM
Slides

GNU MCSim tutorial 3 - Markov Chain Monte Marlo Calibration

May 23, 2019 12:00 PM
Slides
See all talks

Projects

*
All PBPK Modeling Mixture Toxicity Occupational Risk

P42 ES027704

Comprehensive Tools and Models for Addressing Exposure to Mixtures During Environmental Emergency-Related Contamination Events

U01 FD005838

Enhancing the Reliability, Efficiency, and Usability of Bayesian Population PBPK Modeling

ILOSH104-A310

Assessing the Fine Particles-Associated Health Risks for Workers in Workplace

STAR RD83561201

Toxicogenetics of Tetrachloroethylene Metabolism and Toxicity - Using Collaborative Cross Mouse Population Approach to Address …

ILOSH103-A307

Assessing Health Risks for Workers in High Lead Exposed Factories

Publications

Bayesian Population Analysis of Age-Related Physiologically Based Pharmacokinetic Model of Pyrethroids in Rats

Poster

Risk Characterization and Probabilistic Concentration–Response Modeling of Complex Environmental Mixtures Using New Approach Methodologies (NAMs) Data from Organotypic in Vitro Human Stem Cell Assays

Abstract Background: Risk assessment of chemical mixtures or complex substances remains a major methodological challenge due to lack of …
PDF Project Source Document DOI

A Bayesian Population Compartmental Absorption and Transit Modeling Approach to Support Generic Drug Development: Application to Bupropion Hydrochloride Oral Dosage Forms

Project Poster
See all publications

Softwares

    📦MCSim
    A simulation and statistical inference tool for algebraic or differential equation systems

    📦pksensi
    An R package to apply global sensitivity analysis in physiologically based kinetic modeling
    CRAN\_Status\_Badge

Tags

bayesian BMD BPb concentration–Response decision environmental mixtures in Vitro lead meta analysis Metabolism mixtures new approach methodologies occupational risk PBPK pharmacokinetics PM2.5 pop-pk Pyrethroids R Risk risk assessment sensitivity Tetrachloroethylene toxicodynamics toxicokinetics trichloroethylene workshop